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Comparison of rocuronium-induced neuromuscular blockade in second trimester pregnant women and non-pregnant women - 14/6/2018


Int J Obstet Anesth 2018; 34: 10-14.

Introduction

This study set out to compare the onset and duration of rocuronium-induced neuromuscular blockade in second trimester pregnant women and non-pregnant women receiving general anaesthesia.

Methods


A total of 47 pregnant (Group P) and 47 non-pregnant (Group C) women were enrolled. Anaesthesia was induced with propofol 2.0?mg/kg and rocuronium 0.6?mg/kg, and neuromuscular blockade was assessed with an accelerometric sensor using train-of-four stimulation. Tracheal intubation was performed at maximum depression of the first twitch (T1), and anaesthesia was maintained with sevoflurane 1.5–2.5% and 50% oxygen in air. The times to maximum T1 depression and 5% and 25% T1 recovery were recorded, as well as the mean arterial pressure and heart rate at baseline, injection of rocuronium, intubation, and 5% and 25% T1 recovery.

 

Results


The onset of rocuronium-induced neuromuscular blockade (time to maximum T1 depression) did not differ significantly between the groups. The duration (time to 25% T1 recovery) was significantly longer in Group P than in Group C (45.7?±?12.9?minutes versus 40.6?±?10.4?minutes; p<0.037). During the recovery period from the blockade, the mean arterial pressure was significantly lower in Group P than in Group C.

 

Conclusion


The authors found that the rocuronium-induced neuromuscular blockade did not significantly differ in onset but lasted significantly longer in second trimester pregnant women compared with non-pregnant women.


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ArticleDate:20180614
SiteSection: Abstracts



 
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