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Primary Viva 7 (Pharmacology)

Created: 14/9/2004

1. What are the characteristics of an ideal inhalational anaesthetic agent?

2. How do sevoflurane and isoflurane measure up to these characteristics?

3. What type of compound is compound A?

4. What are its effects in man?

5. Why is it nephrotoxic in animals but not in humans?

6. Which compounds form CO with dry soda lime, and why?

7. How do heparin and warfarin work?

8. Where is heparin found in humans?

9. Is it an acidic or a basic compound?

10. How are its actions reversed?

11. What are the side-effects of protamine?

12. What are the side-effects of heparin administration?

13. What are the advantages of low molecular weight heparins (LMWHs)?

14. Describe what is meant by “Michaelis–Menton kinetics”.

15. Draw a graph of reaction velocity vs substrate concentration, and define first order/zero order kinetics.

16. Draw the structure of GABA receptors, showing their various binding sites.

17. Describe the structure of the NMDA receptor.

18. What would be your actions if you inadvertently gave a patient a syringe of suxamethonium?

19. What are the modes of action of the common anti-asthmatic drugs?

20. Discuss the pharmacology of adrenoreceptors.

21. Discuss the action of steroids.

22. How do antiepileptic agents work? (include mention of carbamazepine, phenytoin, benzodiazepines and their receptors)

23. How would you anaesthetise a sick diabetic patient for amputation of an infected leg?

24. What complications of diabetes have an effect on the administration of anaesthesia?

25. Discuss the technical aspects of spinal anaesthesia

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