Search our site 
Advanced Search
Home | News | Exam dates | Contact us | About us | Testimonials |

You are in Home >> Resources >> Pharmacology >> Pharmacology

Metabolism of drugs

Created: 28/7/2004

Metabolism in the liver into inactive compounds which are inactive and more ionised and therefore excreted by the kidney.

Other sites

  • suxamethonium and mivacurium: plasma cholinesterases
  • esmolol: erythrocyte esterases
  • dopamine: kidney
  • prilocaine: lungs

Active Metabolites











Prodrugs: inactive form administered which is converted into an active metabolite






water soluble at acid pH in ampule, becomes more lipid soluble after injection

Phase I and Phase II Reactions

Phase I: reduction, hydrolysis and oxidation

  • oxidation: occurs at the smooth endoplasmic reticulum by cytochrome p450
  • oxidation: can also perform reduction reactions
  • hydrolysis: important in metabolism of ester and amide drugs

Phase II: conjugation of the drug or metabolite with an endogeous substrate

  • conjugation with glucuronic acid, sulphate and glycine
  • acetylation
  • methylation

Induction and inhibition

Some drugs can induce the activity of enzyme systems, particularly cytochrome p450 and glucuronyl transferase.

Some drugs can inhibit the action of enzymes e.g. etomidate; inhibits the synthesis of cortisol and aldosterone (increased mortality seen with infusions)

SiteSection: Article
  Posting rules

     To view or add comments you must be a registered user and login  

Login Status  

You are not currently logged in.
UK/Ireland Registration
Overseas Registration

  Forgot your password?

Latest Discussion - is for sale (Anesthesia Usa)

Hundreds of thousands of premium domains

Questions? We're here to help! Call today:

1-303-893-0552 is for sale

Buy Now: $2095
  • Take Immediate ownership
  • Transfer the domain to the Registrar of your choosing
Finance This Domain: $2095 12 monthly payments of $175
  • 12 monthly payments, only $174.58 per month
  • Start using the domain today See details

Talk to a domain expert: 1-303-893-0552

Hurry - once it's sold this opportunity will be gone!

Besides being memorable, .com domains are unique: This is the one and only .com name of it's kind. Other extensions usually just drive traffic to their .com counterparts. To learn more about premium .com domain valuations, watch the video below:

Turbocharge your Web site. Watch our video to learn how.

Improves Your Web Presence

Get noticed online with a great domain name

73% of all domains registered on the Web are .coms. The reason is simple: .com is the where most of Web traffic happens. Owning a premium .com gives you great benefits including better SEO, name recognition, and providing your site with a sense of authority.

Here's What Others Are Saying

Since 2005, we've helped thousands of people get the perfect domain name
  • My very first experience with, they assisted me in a very professional manner. The agent was knowledgeable and helpful. It was easy as 1-2-3. I was very impressed. "You cannot make a second 'first impression' ". - Ray A.,, 4/11/2017
  • Fast and safe - LiJuan Wu,, 4/6/2017
  • In the film industry, having an online presence is a must and HugeDomains made it incredibly easy to acquire my domain at an affordable price! - Michael B.,, 4/3/2017
  • More testimonials

Own this domain today

Our Price: $2,095 (USD)

Speak with a domain specialist!
Call us: 1-303-893-0552 M-F 9am - 5pm MST
Other Domains You Might Like

© 2017 All rights reserved.


This section is sponsored with an educational grant by Organon.

All rights reserved © 2016. Designed by AnaesthesiaUK.

{Site map} {Site disclaimer} {Privacy Policy} {Terms and conditions}

 Like us on Facebook