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Drug excretion

Created: 6/4/2004

 

Ionised compounds

  • Excreted mainly by renal mechanisms

  • Ionisation is a barrier to reabsorption

  • Basic drugs excreted more in acid urine

  • Acid drugs excreted more in alkaline urine

Active secretion

Penicillins
Aspirin
Diuretics
Morphine
Lidocaine
Glucuronides

Secretion in bile

Generally larger molecules (MW >400)
Glycopyrronium
Vecuronium
Pancuronium
Morphine-6-glucuronide
 

 


ArticleDate:20040406
SiteSection: Article
 
   
    
                                            
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