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This resource section is sponsored by an educational grant from MSD.



Vecuronium

Created: 23/11/2004
Updated: 9/5/2017
 

Chemical


A bis-quaternary aminosteroid, which is the mono-quaternary analogue of pancuronium.



Presentation


It is a short-acting relaxant, prepared as a powder, which is dissolved in sterile water immediately prior to use, to yield a clear solution 2 mg/ml.

Cardiovascular effects


These are minimal, although the potential problems listed under atracurium apply. Histamine release is not a feature, and placental transfer is minimal.

Distribution, metabolism and excretion


Vecuronium is excreted both in the bile and urine. Its action is slightly prolonged in renal impairment. In the liver, vecuronium undergoes deacetylation to the active metabolites 3- and 17-hydroxy- and 3,17-dihydroxyvecuronium.

Dose administration and use


An IV dose of 0.08-0.1 mg/kg will produce relaxation for 15-30 minutes and supplemental doses should be 1-2 mg.

Storage


Vecuronium powder does not need to be refrigerated.


ArticleDate:20041123
SiteSection: Article
 
   
    
                                            
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