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Primary Viva 11 (Pharmacology)

Created: 7/9/2004
1. Describe the appearance of a plasma concentration–time graph for a drug.

2. What do you understand by the term “exponential”?

3. How else could these data be presented?

4. What information could you gain from the graph?

– Derive the volume of distribution (Vd), clearance (CL), elimination half-life (t½) and the elimination rate constant (K)

– What is the context-sensitive half time?

– Discuss how to calculate dosing intervals in relation to the data derived.

– Discuss one-, two- and three-compartment models, comparing muscle relaxants and propofol
as an example.

5. Discuss the uses, presentation and mode of action of non-steroidal anti-inflammatory drugs (NSAIDs).

– What is the difference between COX-1 and COX-2 inhibition, and the respective side-effects?

 – Discuss prostaglandins, thromboxanes, prostacyclin and leukotrienes.

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