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Minimum Alveolar Concentration (MAC)

Created: 4/1/2007
Updated: 4/1/2007
MAC is a measure of potency and is defined as the minimum alveolar concentration at steady-state that prevents reaction to a standard surgical stimulus (skin incision) in 50% of patients at 1 atmosphere (i.e. sea level). This measurement is done at steady state (assuming a constant alveolar concentration for 15 minutes), under the assumption that this allows for an equilibration between the gasses in the alveoli, the blood and the brain

End-tidal agent monitoring is used by modern anaesthetic monitors to calculate MAC.

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