Paper typeRandomised controlled trial
ReferenceEsteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C et al.
Noninvasive positive-pressure ventilation for respiratory failure after extubation.
New England Journal of Medicine 2004; 350: 2542-2560
Major FindingIn patients who have respiratory failure post extubation noninvasive ventilation does not reduce reintubation rates and increases mortality.
Point for discussion:
If NIV is started earlier in those patients with respiratory failure post-extubation or selectively used in COPD patients, would re-intubation rates actually be reduced?