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Ferrer et al. Pre-emptive NIV post extubation. AJRCCM 2006.

Created: 16/5/2007
Updated: 16/5/2007

Paper type

Randomised controlled trial


Ferrer M, Valencia M, Nicolas JM et al.
Early Non-invasive Ventilation Averts Extubation Failure in Patients at Risk. A Randomised Controlled Trial.
Am J Respiratory and Critical Care Medicine 2006. Vol 173.pp 164-170

Major Finding

The use of early non-invasive ventilation in patients at high risk of extubation failure can reduce the risk of respiratory failure (NNT 6) but has no effect on re-intubation rates, hospital mortality or ICU length of stay.

Point for discussion:

As 50% of the patients in this study had COPD, is this further evidence that we should have a low threshold to extubate these patients to NIV?

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