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Bernard et al. The PROWESS trial. NEJM 2001

Created: 17/5/2007
 

Paper type

Randomised Controlled Trial

Reference

Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF et al.
Efficacy and safety of recombinant human activated protein C for severe sepsis.
New England Journal of Medicine 2001; 344: 699-709.

Major Finding

For every 16 patients with sepsis given activated protein C, compared to placebo, one less patient dies. The risk of bleeding complications may be increased.

Point for discussion:

As a result of the extensive correspondance relating to this and the subsequent APC trials are ICU clinicians as keen to prescribe APPC as they were when this study was first reported?

ArticleDate:20070517
SiteSection: Article
 
   
    
                                            
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