Systematic Review and meta-analysis
Turgeon AF, Hutton B, Fergusson DA et al.
Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis.
Annals of Internal Medicine 2007; 146: 193-203
A survival benefit was observed for patients with sepsis who received polyclonal intravenous immunoglobulin therapy compared with those who received placebo or no intervention.
Point for discussion:
A large, randomized, controlled trial of polyclonal intravenous immunoglobulin therapy should be performed on the basis of the methodological limitations of the current literature. What is the potential benefit from this therapy in more severely ill patients? What is the potential effect of dosage and duration of this therapy?