Randomised controlled trial
Merten GJ, Burgess WP, Gray LV et al.
Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.
JAMA 2004 291; (19):2328-34
Hydration with sodium bicarbonate before contrast exposure is more effective than hydration with sodium chloride for prophylaxis of contrast-induced renal nephropathy.
Point for discussion:
But should we prescribe sodium bicarbonate, n-acetyl cysteine or sodium bicarbonate AND n-acetyl cysteine?