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Schmidt et al. NAC and NaHCO3 to prevent contrast nephropathy. Ann Pharm 2007

Created: 22/5/2007

Paper type

Retrospective cohort


Schmidt P, Pang D, Nykamp D et al.
N-acetylcysteine and sodium bicarbonate versus N-acetylcysteine and standard hydration for the prevention of radiocontrast-induced nephropathy following coronary angiography.
Ann Pharmacother 2007; 41(1):46-50.

Major Finding

The addition of sodium bicarbonate to N-acetylcysteine  does not appear to confer additional protection against the development of radiocontrast-induced nephropathy.

Point for discussion:

Prospective, randomized, placebo-controlled trials are warranted to definitively determine how best to prevent radiocontrast-induced nephropathy ?

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