Schmidt P, Pang D, Nykamp D et al.
N-acetylcysteine and sodium bicarbonate versus N-acetylcysteine and standard hydration for the prevention of radiocontrast-induced nephropathy following coronary angiography.
Ann Pharmacother 2007; 41(1):46-50.
The addition of sodium bicarbonate to N-acetylcysteine does not appear to confer additional protection against the development of radiocontrast-induced nephropathy.
Point for discussion:
Prospective, randomized, placebo-controlled trials are warranted to definitively determine how best to prevent radiocontrast-induced nephropathy ?