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Hill et al. Systematic review of transfusion triggers. Cochrane review

Created: 22/5/2007
Updated: 22/5/2007

Paper type

Systematic Review


Hill SR, Carless PA, Henry DA et al.
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.
Cochrane Database of Systematic Reviews 2000

Major Finding

The limited published evidence supports the use of restrictive transfusion triggers in patients who are free of serious cardiac disease. However, most of the data on clinical outcomes were generated by a single trial. The effects of conservative transfusion triggers on functional status, morbidity and mortality, particularly in patients with cardiac disease, need to be tested in further large clinical trials. In countries with inadequate screening of donor blood the data may constitute a stronger basis for avoiding transfusion with allogeneic red cells.

Point for discussion:

Does this review add to the trial Herbert et al or merely emphasise their findings?

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