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Primary viva 30 (Pharmacology)

Created: 8/4/2011
1. What methods of drug administration do you know?
- Which drugs can be given intranasally?
- What is des-amino D-arginine vasopressin (DDAVP)?
- How should this be administered and why?
- What affects drug absorption?
- What features affect the transdermal absorption of a drug?

2. What is bioavailability?
- How would you calculate it?
- Draw a graph illustrating this.
- How is the area under the curve calculated?
- How could you do this without using a computer or integration?

3. Discuss the differences between halothane and sevoflurane.
- What are the blood gas solubilities of halothane and sevoflurane?
- Draw a graph illustrating the relative blood gas solubilities of these agents.
- Why do we use alveolar concentration/inspired gas concentration (FA/Fi) on the y axis?
- If you had an agent with a blood gas solubility of 0.4, where would it fit on the graph?
- What factors affect the uptake of volatile agents?
- What would happen to the curves if the cardiac output decreased?
- What would happen if Fi was increased?
- At what time point would the lines all converge?

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