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Primary Viva 39 (Pharmacology)

Created: 8/8/2014
1. Classify anticholinergic agents.
- Name some acetylcholinesterase inhibitors.
- Which of these crosses the blood-brain barrier?
- Discuss the mechanism of action of anticholinergic agents, the structural basis of their action, duration etc.
- Why is atropine used for reversal of neuromuscular blockade?
- Draw the neuromuscular junction and the site where neuromuscular receptors and cholinesterase are present.
- Discuss the mechanism of action of organophosphates and give examples.
- Discuss atropine psychosis.
- Describe the Tensilon test in detail.

2. Name the different routes of drug administration.
- What are the characteristics of drugs given orally?
- Describe first pass metabolism.
- What is the extraction ratio?
- How can a drug bypass the liver?
- What are the characteristics of drugs given transdermally? Give examples.
- What are the problems associated with rectal administration?
- What is bioavailability? Draw a graph to illustrate your answer.

3. Classify diuretics, giving examples of each.
- Describe the mechanism of action of each, explaining which channels each of them blocks.
- Which of these acts at the glomerular level?
- Describe the mechanism of action of carbonic anhydrase inhibitors.

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