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You are in Home >> Resources >> Pharmacology >> Neuromuscular blockade and reversal


Created: 23/11/2004
Updated: 13/6/2019


A bis-quaternary aminosteroid, which is the mono-quaternary analogue of pancuronium.


It is a short-acting relaxant, prepared as a powder, which is dissolved in sterile water immediately prior to use, to yield a clear solution 2 mg/ml.

Cardiovascular effects

These are minimal, although the potential problems listed under atracurium apply. Histamine release is not a feature, and placental transfer is minimal.

Distribution, metabolism and excretion

Vecuronium is excreted both in the bile and urine. Its action is slightly prolonged in renal impairment. In the liver, vecuronium undergoes deacetylation to the active metabolites 3- and 17-hydroxy- and 3,17-dihydroxyvecuronium.

Dose administration and use

An IV dose of 0.08-0.1 mg/kg will produce relaxation for 15-30 minutes and supplemental doses should be 1-2 mg.


Vecuronium powder does not need to be refrigerated.


Evaluation of neuromuscular blockade with vecuronium during general anesthesia with oxygen, nitrous oxide, isoflurane versus oxygen, air, isoflurane: a randomized controlled study. Anesth Essays Res 2019; 13(1): 44-9. 

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