General population
Reported between 1:5000 and 1:200 000.
Familial
Most affected families have a dominant pattern of inheritance. However, there is a variable penetrance and expressivity of the disease. This occurs on second or later triggering anaesthetic in 1/3 of cases, but all are thought to be picked up by contracture testing.
Genetics
At least four chromosomal locations have been identified: Best defined is the Ryanodine receptor on 19q13 Also 17, 7, and 3.
ArticleDate:20040413
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