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Created: 6/4/2004


The steroid dexamethasone (150 mcg/kg in children or 8 mg in adults) is used for reduction of nausea and vomiting related to chemotherapy and has been shown to be useful in the treatment of postoperative nausea and vomiting. The mode of action is unclear; it may be due to decreased release of arachidonic acid, reduced turnover of 5-hydroxytryptamine or decreased permeability of the blood-brain-barrier.


[i] Dexamethasone prevents postoperative nausea and vomiting more effectively in women with motion sickness.
Lee Y et al.
Can J Anaesth 2003; 50(3): 232-7.

[ii] The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting.
Lee Y et al.
Anaesthesia 2002; 57(7): 705-9.

[iii] Excruciating perineal pain after intravenous dexamethasone.
Neff SP et al.
Anaesth Intensive Care 2002; 30(3): 370-1.

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