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Benzodiazepines

Created: 16/12/2005
 

Lorazepam

Structure

The structure of Lorazepam

Lorazepam is a potent benzodiazepine with profound sedative and amnesic properties. It is also used as an antiemetic during chemotherapy. It is postulated that Lorazepam modifies central pathways involved in nausea and vomiting. The amnesic activity also prevents anticipatory vomiting associated with chemotherapy.


References

[i] Clinical efficacy of lorazepam in prophylaxis of anticipatory, acute, and delayed nausea and vomiting induced by high doses of cisplatin. A prospective randomized trial.
Malik IA et al.
Am J Clin Oncol 1995; 18(2): 170-5.

[ii] The antiemetic effect of lorazepam after outpatient strabismus surgery in children.
Khalil SN et al.
Anesthesiology 1992; 77(5): 915-9.


ArticleDate:20051216
SiteSection: Article
 
   
    
                                            
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